IL22 and hepatocellular carcinoma: IL17 signaling genes significantly upregulated in HCC included Il17a/f, Il17a transcription regulators Rorc, Runx1, and Hif1a, upstream regulatory cytokines Il6, Il23a, and their receptors, as well as Th17 cell downstream signaling Il22, Ccl20, Ccr6, S100a8, and S100a9. miR-22 treatment suppressed all these IL17 signaling genes (Figure 4A).