HCC increased the expression of glycolysis-related genes including Pfkfb4, Pkm, Aldoa, Eno1, Pgam1, Slc2a1, Pfkl, and Gpi1. 42Whereas, two known HIF1α-suppressed lipid metabolism-related genes, Ppara (fatty acid oxidation) and Chka (phospholipid synthesis), were reduced in HCC livers.43 This evidence concerns the gene PFKL and hepatocellular carcinoma.