In the orthotopic xenograft tumor mouse models established with PDX cell lines, animals subcutaneously implanted with PDX-vector-shSOX9/SOX2/OCT4-shFTH1/FTL/TFRC or PDX-c-Jun-OE-shSOX9/SOX2/OCT4-shFTH1/FTL/TFRC cell lines exhibited comparable tumor burdens and tumor weights after GEM treatment (Fig. 9F-G). This evidence concerns the gene JUN and neoplasm.