The results of the TUNEL assay and Ki67 immunofluorescence staining in mouse pancreatic tumor indicated that a higher proliferative capacity and lower apoptotic rate in PDO-c-Jun-OE tumors than in PDO-vector tumors, and that c-Jun overexpression increased the resistance of PDAC tumors to the cytotoxic effects of GEM (Fig. 6J-K). This evidence concerns the gene JUN and pancreatic neoplasm.