The study[46]found that CD31+ EMVs (endothelium-derived microvesicles) in the blood of patients progressively increased with the progression of the coronary atherosclerotic process, with the highest expression in patients with acute myocardial infarction, strongly suggesting that endothelium-derived microvesicles are associated with myocardial damage. The gene discussed is PECAM1; the disease is acute myocardial infarction.