Myocardial infarction size (expressed as percentage of area at risk, Fig. 3G-H), ROS levels (Fig. 3I and J), and TUNEL-positive cell rate (Fig. 3K and L) were significantly increased in the IR + HR-EMVs mice compared with the IR + PBS group, with a concomitant increase in the expression of the pro-apoptotic proteins Bax and cleaved caspase-3 and a significant decrease in Bcl2 (Fig. 3M and N). The gene discussed is BCL2; the disease is myocardial infarction.