In human pancreatic cancer tissues, Ohlund et al. have found two major CAFs, one called myofibroblastic CAF (myCAF), which is located close to cancer cells and expresses high levels of α-SMA and FAP, has high levels of ECM-related genes, and is enriched in the TGF driver pathway. This evidence concerns the gene ACTA1 and familial pancreatic carcinoma.