Goetz JG et al. have found that Cav-1 expression is significantly higher in breast cancer CAFs than in NFs and that the 10-year risk of death is 2.5-fold higher in patients with Cav-1high than in controls, suggesting that Cav-1 in CAFs has the potential to improve tumor cell invasion and metastasis by regulating Rho-mediated cell contractility in a p190-dependent manner, remodeling the tumor stroma and intra-tumor microenvironment and hardening the TME [228]. This evidence concerns the gene CAV1 and breast carcinoma.