POSTN overexpression in CAFs is associated with many adverse clinicopathological factors, such as higher T and clinical stages and a larger tumor volume in NSCLC [72]; highly cell-rich and macrophage-infiltrated pancreatic cancer [73]; and lymph node metastasis and distant metastasis in pancreatic cancer and CRC [69, 73]. This evidence concerns the gene POSTN and familial pancreatic carcinoma.