In a mouse model of pancreatic cancer, FAP+ CAFs are the main source of CXCL12 that combines with CXCR4 on the surface of cancer cells and marginalized T cells through a CXCL12–CXCR4 signaling mechanism, leading to tumor immunosuppression [21]. The gene discussed is CXCR4; the disease is familial pancreatic carcinoma.