α-SMA+ CAFs are associated with worse prognosis in oral tongue squamous cell carcinoma (OTSCC) [43], head and neck squamous cell carcinoma (HNSCC), EAC, colon cancer [44], prostate cancer [45], breast cancer [37], and bile duct cancer [36, 46]. This evidence concerns the gene ACTA1 and head and neck squamous cell carcinoma.