With current information, it can be inferred that the dysregulation of protein lipoylation on DBT and DLAT due to aberrant copper accumulation can affect the TCA cycle, at the same time, the dysregulation expression of obesity-related gene DLAT influences the energy metabolic in ER+ BC cells and microenvironment, ultimately affecting the responses to specific drugs and BC prognosis. This evidence concerns the gene DLAT and Obesity.