KDR and neoplasm: Beyond this, ATP7A is also described to be involved in autophagy, and vascular endothelial growth factor receptor 2 (VEGFR2) degradation in endothelial cells, the loss of ATP7A inhibits angiogenic responses via VEGFR2 signaling [51], while the tumor-stimulated neovascularization is considered as a key step during tumor progression.