PTGS2 and rheumatoid arthritis: Consistently, our previous studies demonstrated that a clinically prescription for the treatment of RA-Cold Wutou Decoction (WTD) may effectively relieve the disease severity by regulating the ALOX15B-PPAR-γ-PTGS2-FGF2-IL1β-cJUN-MM13-TGFβ1 signaling axis which may be associated with the balance maintenance of “inflammation-immune” system, the production of body heat and the regulation of energy metabolism [9].