These findings suggest that T cell immunity may be disturbed under the cold stimulation, in accord with our data that “IL-17 signaling pathway” and “T cell differentiation” may be associated with the main pathological changes of RA-Cold, such as RA synovial cell migration, autophagy, and chemokine production [20, 33–35]. The gene discussed is IL17A; the disease is rheumatoid arthritis.