NLRP3 and rheumatoid arthritis: In contrast, VEAGFA–VEGFR2 signaling, sphingolipid signaling and NLRP3 inflammasome, enriched by most RA-Hot kay network targets, have been reported to play roles in synovial pannus hyperplasia, energy metabolism (especially lipid metabolism), and nervous system regulation of RA patients [22–24] (Fig. 2G, H).