In conclusion, the current study may offer evidence that the development and progression of RA-Cold may be associated with T cell immune regulation, phenylalanine and tryptophan metabolism pathway, while RA-Hot may be mainly related to the disturbance of sphingolipid metabolism, glutamine metabolism, NLRP3 and VEGF angiogenesis signal pathways. Here, VEGFA is linked to rheumatoid arthritis.