Whereas STING facilitates antitumor immune response by promoting the infiltration of effector cells and eradication of tumor cells, constant STING activation may hamper immune response by inducing the infiltration of immune suppressive cells, such as Treg and MDSC, and upregulating the expression of PD-L1 on tumor cells and PD-1 on T cells. This evidence concerns the gene CD274 and neoplasm.