Galindo-Pumariño et al. generated an ECM model by using normal fibroblast, CAFs, and cell lines (fibroblast and tumor cells) and identified its role in the cetuximab-resistance processes of colorectal cancer (CRC) cells mediated by SNAI1-expressing fibroblasts in vitro and also showed the matrices generated by Snai1-knockout mouse embryonic fibroblasts (MEF) confer less resistance on cetuximab than wild-type MEF-derived matrices in vivo. This evidence concerns the gene SNAI1 and colorectal carcinoma.