They showed the recruitment of absent in melanoma 2 (AIM2), a DNA-sensing protein for the activation of the caspase-1 inflammasome, to the phagosomes following ADCP and activated by sensing the phagocytosed tumor DNAs, subsequently upregulating PD-L1 and indoleamine 2, 3-dioxygenase and causing immunosuppression in TME [76]. The gene discussed is CD274; the disease is neoplasm.