In our downstream analysis performed to explore these alternatives, 17 pleiotropic loci between depression and BC were identified, harboring genes which were previously implicated in neural development and brain functions (i.e., HCN1, ABT1, ZSCAN12, ZNF184, KLC1, MKL1, SGSM3, CCDC91), or biological processes related to tumor growth (i.e., ABT1, ZSCAN12, ZNF184, KLC1, TTC28, MKL1, CCDC91, OLFM4, DDR1). Here, ZSCAN12 is linked to major depressive disorder.