SOD1 and amyotrophic lateral sclerosis: Multiple compounds have been shown to be effective in SOD1 transgenic mice, and may well have proved beneficial in SOD1-ALS patients; one example is the heat-shock protein co-inducer arimoclomol, which performed well in preclinical SOD1-ALS transgenic mouse studies [82] and was taken to a double-blind, placebo-controlled trial in 38 patients with rapidly progressing SOD1-ALS, 19 of whom were given placebo, 17 given arimoclomol.