TARDBP and amyotrophic lateral sclerosis: Crucially, TDP-43 deposition is not specific for ALS, as it has been found in other disorders such as Alzheimer’s disease [47], polyglutamine diseases [48], limbic-predominant age-related TDP-43 encephalopathy (LATE) [49], and as a result of neurological insults, including methyl mercury exposure [50] and hypoperfusion [51].