In line with that, RNA expression data of sorted NKG2D-L negative AML patient cells (with stem cell properties) revealed a significantly lower KLF4 expression as compared to NKG2D-L positive AML patient cells (no stem cell properties) (p = 4.4 × 10–44, see supplement in [13]). This evidence concerns the gene KLF4 and acute myeloid leukemia.