Besides HDACi, DNA damage, e.g. caused by chemotherapeutics, also is known to result in an upregulation of MICA. To explore the role of KLF4 in DNA damage-mediated MICA induction, we analyzed the expression of KLF4 and MICA in the AML cell line HL60 in response to cytarabine (araC), a drug known to induce DNA damage in AML [24]. Here, KLF4 is linked to acute myeloid leukemia.