Moreover, we found that in PLWH with COPD, reduced Prevotella abundance was correlated with the increased methylation of CpG sites along the genes PHLDB3 and FUZ, and the decreased expression of gene FUZ and the increased expression of gene FASTKD3. The consistent appearance of FUZ in relation to Prevotella abundance in our multi ‘omic integration analyses suggests a strong relationship between these two features along both epigenetic and transcription pathways. This evidence concerns the gene FUZ and chronic obstructive pulmonary disease.