The preoperative PRL levels in the cystic prolactinomas patients who underwent surgical removal for inadequate tumor shrinkage were 64.50 ± 18.41 ng/ml, which was significantly lower than the other groups (p = 0.001 vs. patients’ preferences (509.96 ± 105.09 ng/ml), p = 0.017 vs. DA-intolerance (479.70 ± 263.22 ng/ml), p = 0.012 vs. persistent hyperprolactinemia (396.11 ± 63.44 ng/ml); Fig. 1C). This evidence concerns the gene PRL and neoplasm.