As a result of the higher affinity of 2-BI for both A1/A2A AR compared to caffeine, and the structural similarity to caffeine, the current pilot study was initiated to establish the possible antidiabetic effect of 2-BI, by exploring its ability to suppress intestinal glucose absorption and attenuate hyperglycemia in fructose-streptozotocin (STZ) diabetic rats. This evidence concerns the gene AR and Hyperglycemia.