Based on these results, a similar study on European sea bass identified the I-IFN system as an important player in its protection against RGNNV infection using different in vivo approaches [52]. Thus, based on the results obtained on the regulation of viral infections in humans but also in several aquaculture species, resistance to NNV in sea bass could be related to the interferon pathway via the regulation of the IFI6/IFI27-like protein encoded by the gene positioned on LG12. Here, IFI6 is linked to viral infectious disease.