However, in vitro experiments showed that zinc finger DHHC domain–containing palmitoyltransferases can enhance the activity of interferon-induced transmembrane protein 3 (IFITM3), which is a cellular endosome- and lysosome-localized protein that restricts numerous virus infections, and its activation by ZDHHC has antiviral properties [44]. This evidence concerns the gene IFITM3 and viral infectious disease.