While the increase in endometrial staining of ADRB2 in women of in-pandemic group as compared with the pre-pandemic group does not seem to impact other markers that we evaluated, it is possible it may contribute to menstrual irregularity [21, 22], decreased duration of menstruation and volume of menstrual blood loss [23], and newly onset of dysmenorrhea [22]. The gene discussed is ADRB2; the disease is Dysmenorrhea.