Of these, 6 proteins are earlier reported to be associated with LN metastasis in GBC (KRT7, KRT19, VIM, PKM, LASP-1, TYMP), 33 proteins are associated with LN metastasis in other cancers (NPM1, SRI, FABP5, PPIA, HSPA9, AOC3, ANXA2, ANXA5, ANXA10, TAGLN2, HNRNPK, CAPG) while 19 proteins (DLST, MDH2, CKMT1A, APOC3, RDH16, VCAN) are novel to LN metastasis in cancer (Supplementary Table S4). The gene discussed is APOC3; the disease is cancer.