Methylation at sites detected by the following probes exhibited a negative connection with LILRB1 gene expression: cg02340056 (r = -0.339, P < 0.001), cg24154699 (r = -0.262, P < 0.001), cg13762704 (r = -0.243, P < 0.001), cg26778001 (r = -0.171, P < 0.001) in LGG and cg02340056 (r = -0.462, P < 0.001) in GBM, but a positive correlation with LILRB1 gene expression cg24154699(r = 0.379, P < 0.01), cg13762704(r = 0.296, P < 0.05) in GBM, no conclusive link with LILRB1 gene expression cg26778001(r = -0.142, P > 0.05) in GBM. The gene discussed is LILRB1; the disease is glioblastoma.