KMT2D and acute myeloid leukemia: Gene set enrichment analyses (GSEA) further confirmed the enrichment of genes implicated in the aforementioned biological processes, with the gene signature of KEGG_RIBOSOME, GO_NUCLEOLAR_PART, GO_RRNA_METABOLIC_PROCESS, and REACTOME_TRANSLATION being significantly positively enriched in Kmt2d knockdown AML cells compared to Kmt2d restored cells (Figure 3J).