To define HCC- or CRLM-intrinsic tumor features on liver TME, CXCR4, CXCL12, N-cadherin (N-cad), vimentin (Vim), CXCL5, and CXCL8 expression was evaluated in HCC and CRLM tissues. This evidence concerns the gene CXCL12 and hepatocellular carcinoma.