IFNG and hepatocellular carcinoma: Accordingly, in supernatants of Teffs:Tregs coculture, IL-35 increased from PB-HCC and PB-CRLM as compared to HD (Supplementary Fig. 6a, b), and IFNγ was reduced in PB-HCC and PB-CRLM as compared to Teff alone (Supplementary Fig. 7).