In the study, higher expression of Arg-1 was reported at the peritumoral site in both tumors and higher expression of CCL5 at the peritumoral site in CRLM; notably, the increased immunosuppressive Arg-1 and CCL5 in HCC compared to CRLM emphasizes the existence of an HCC-TME strongly oriented toward immunosuppression. Here, CCL5 is linked to hepatocellular carcinoma.