CXCR4 was overexpressed in Tregs from TT-CRLM as compared to PT; interestingly, ENTPD1 was significantly overexpressed in TT-HCC as compared to TT-CRLM (p < 0.05) (Fig. 2aii, Supplementary Fig. 1b and 2b). The gene discussed is CXCR4; the disease is hepatocellular carcinoma.