Herein, HCC and CRLM patients’ peripheral Tregs displayed a robust activated phenotype CTLA4+, CXCR4+, PD-1+, and ENTPD-1+, while higher ICOS+ Tregs, potent and suppressive in immune escape, [41] were detected only in HCC patients. The gene discussed is ENTPD1; the disease is hepatocellular carcinoma.