Second, given the importance of STING in tumour immunity, we next assessed the role of myeloid-specific SEL1L–HRD1 ERAD in tumorigenesis following subcutaneous implantation of tumour cells from spontaneous tumours derived from KrasLSL-G12D;Trp53LSL-R172H;Pdx1-Cre mice with pancreatic ductal adenocarcinoma into Sel1LLyz2 or Sel1Lf/f mice. The gene discussed is PDX1; the disease is pancreatic ductal adenocarcinoma.