CUT&Tag analysis45 revealed that H3K27me3 peaks were enriched globally and at SASP-related gene loci in KPC1 PDAC tumor cells FACS sorted from tumors grown in the pancreas (PIP) in vivo as compared to KPC1 PDAC cells grown in vitro, including for instance at Ccl2, Ccl5, Ccl7, Ccl8, and Cxcl10 loci that are transcriptionally repressed in the PDAC TME (Extended Data Fig. 4 and Supplementary Tables 23–26). Here, CXCL10 is linked to neoplasm.