CX3CL1 and neoplasm: Further analysis uncovered significantly increased expression of SASP-associated pro-inflammatory cytokines and chemokines (Il15, Ccl2/5/7/8, Cxcl9/10/11, Cx3cl1), as well as genes involved in antigen presentation/processing (B2m, Tap1, Tapbp) and cell adhesion (Icam1) important for T and NK cell recognition of tumor cells in the context of T/P-induced senescence and EZH2 suppression (Fig. 6b and Supplementary Table 46).