T/P-induced senescence in combination with GCV-mediated SMA+ fibroblast depletion led to significantly decreased tumor growth and increased infiltration of NK and CD4+ and CD8+ T cells and their expression of activation (CD69, Sca-1) and cytotoxicity (GZMB) markers compared to T/P treatment alone (Fig. 3c–e). This evidence concerns the gene CD4 and neoplasm.