To understand the impact of EZH2 suppression on senescence-mediated anti-tumor immunity in PDAC, we transplanted KPC1 or KPC2 PDAC cells harboring control Renilla (shRen) or EZH2-targeting (shEzh2) shRNAs orthotopically into the pancreas of C57BL/6 mice (Fig. 5a). Here, EZH2 is linked to neoplasm.