Immunomodulatory cell surface proteins associated with the SASP, including cell adhesion molecules (ICAM-1) important for tumor-lymphocyte synapses, stress ligands that bind and stimulate the activating NKG2D receptor on NK cells (ULBP1, H60a, RAET1D/E), and MHC-I necessary for antigen presentation to T cells, were also strongly upregulated following therapy-induced senescence and EZH2 knockdown (Extended Data Fig. 6b,c). Here, EZH2 is linked to neoplasm.