Given the numerous cell autonomous and non-cell autonomous functions of EZH2 in cancer biology48, we performed bulk RNA-seq on FACS sorted GFP+ tumor cells isolated from drug-treated shRen or shEzh2 PDAC tumors to understand the mechanisms by which EZH2 targeting led to immune-mediated tumor control (Supplementary Table 40). This evidence concerns the gene EZH2 and cancer.