Moreover, whereas T/P treatment reduced H3K27me3 marks at pro-inflammatory SASP genes in KPC1 PDAC cells and induced their expression to a similar degree in KRAS mutant mouse and human pancreatic and lung cancer cell lines in vitro, T/P-induced senescence did not turn on SASP gene expression transcriptionally or reduce repressive H3K27me3 marks in these tumors cells when grown in the pancreas TME in vivo (Extended Data Fig. 4 and 5 and Supplementary Tables 23–26). This evidence concerns the gene RNF123 and lung carcinoma.