CLCC1 and amyotrophic lateral sclerosis: To this end, we performed whole-exome sequencing (WES) in a Chinese cohort (670 sporadic ALS patients and 1910 controls) and identified 8 rare variants in CLCC1 in the patients, including 6 nonsynonymous and 2 stop-gain mutations (Fig. 5a; Supplementary information, Fig. S15 and Table S1).