Mutations of SUZ12 (9.8%) and TNFAIP3 (4.9%) were only detected in STAT3 mutant, while mutations of DNMT3A (7.3%) and IDH1 (4.9%) were only detected in STAT3 wild type after excluding three patients with a concomitant MDS clone. Here, STAT3 is linked to myelodysplastic syndrome.