We found that the biological network predicted by IPA software of DEGs between control and glutamate treatment showed associations with Alzheimer's disease and several canonical pathways, including “neuroinflammation signaling pathway”, “NF-κB signaling”, “apoptosis signaling”, “autophagy”, and “synaptogenesis signaling pathway”. Here, NFKB1 is linked to early-onset autosomal dominant Alzheimer disease.