For the mesenchymal cells, a low H3K27ac signal could be quantified for the super-enhancer regions of the noradrenergic CRC such as GATA3, PHOX2B and HAND1. On the other hand, a high H3K27ac signal could be observed on RUNX1, FOSL1, NR3C1, and TBX18, previously described as NCC-like/mesenchymal transcription factors17 (Fig. 4B, C). The gene discussed is PHOX2B; the disease is colorectal carcinoma.