The master transcriptional regulators controlling the gene expression program of neuroblastoma have been highlighted through the characterization of the super-enhancer landscape of neuroblastoma cell lines, revealing two distinct cell identities: a sympathetic noradrenergic identity defined by a core regulatory circuitry (CRC) module including the PHOX2A/B, HAND1/2 and GATA2/3 transcription factors and a NCC-like/mesenchymal identity, close to that of human neural crest cells (hNCCs), driven by factors of the AP1 family among others17,18. This evidence concerns the gene HAND1 and neuroblastoma.