NOTCH1 and acute lymphoblastic leukemia: In contrast, by using NetBID2, we could reconstruct a T-ALL-specific interactome from RNA-seq profiles of T-ALL primary samples (N = 261) and use the NOTCH1 subnetwork (Fig. 3c) to infer its protein activity, which significantly differentiated mutant cases from wild-type cases (P = 2.2 × 10−7) (Fig. 3b, d).