MBD2 and neoplasm: Intriguingly, we demonstrated that higher expression of MBD2 was observed in tumors of LUAD patients with either lymphatic or distant tumor metastasis than in tumors in situ, but no significant difference in terms of MBD2 expression was noted between normal lung tissues and LUAD tumor tissues by analysis of paired samples from 73 LUAD patients (Fig. 1) and the data from 58 pairs of LUAD patients from the Oncomine database (Supplementary Fig. 1).