TNFRSF10B and neoplasm: Specifically, sub-cytotoxic RT doses (2 Gy delivered in a single fraction) were shown to promote the expression of death receptors (DRs) including TNF receptor superfamily member 10b (TNFRSF10B, best known as DR5 or TRAIL-R2) by cultured PDAC cells, enabling CAR T cells that produced DR ligands as a consequence of initial CAR signaling to mediate sLeA-independent tumor killing [11].