SOX2 and central nervous system cancer: These three tissue-states are further demonstrated by projecting the RNA-expression levels for canonical markers of the predominant cell types for each tissue-state in Fig. 6e showing RBFOX3 (neuronal marker) in tissue-state A, CD68 (myeloid marker) in tissue-state B, and MKI67 (proliferation marker) in tissue-state C. SOX2 (a pan-glioma marker) was widely distributed across the samples, indicating variable degrees of tumor infiltration across samples in all three tissue-states (Fig. 6e).