Fang and colleagues [65] reported that siRNA knockdown of TLR2 remarkably reduced phagocytosis and autophagy during Staphylococcus aureus infection, showing that TLR2 provided an underlying mechanistic link between innate immune receptors and the induction of phagocytosis and autophagy in S. aureus-stimulated macrophages. The gene discussed is TLR2; the disease is staphylococcus aureus infection.