The role played human mesenchymal stem cells in promoting CRC progression in the TME is due to the activation of epithelial-mesenchymal transition (EMT) mediated by the CCL5/CCR1/β-catenin/Slug pathway, indicating that CCL5 is an important factor in the regulation of CRC development through its mediation of stromal cell and cancer cell interaction [61]. This evidence concerns the gene CCR1 and colorectal carcinoma.