Because Txnip has been reported to activate NOD-like receptor family protein 3 (NLRP3) under oxidative stress [40], Txnip may be involved in exacerbating inflammation in addition to inhibiting regeneration in the liver of patients with NASH; in any case, Txnip suppression would improve the pathophysiology of NASH. This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.