In this study, we showed that targeted expression of M46 in pancreatic acinar cells promotes infiltration of myeloid cells (CD11b+), including MDSCs, macrophages, and M2 macrophages, and decreases infiltration of CD3+CD8+ and CD3+CD4+ T cells and T cell activation in the pancreata of KC mice. Here, CD8A is linked to keratoconus.