KRAS and keratoconus: RNA-Seq analyses of the PDAC samples from KMC mice at 9 months and KC mice at 15 months showed that expression of M46 was associated with upregulation of epithelial-mesenchymal transition in addition to upregulation of Kras signaling, inflammatory, and other hallmark pathways observed in pancreata of MC mice treated with cerulein (Figure 7, H–J).