STK11 and obesity due to melanocortin 4 receptor deficiency: Since LPS injection has been reported to acutely increase Ser431-LKB1 phosphorylation in whole lung and liver lysates; in immortalized Raw264.7 macrophages (42), one may hypothesize that obesity-induced endotoxemia might contribute to increased pLKB1 levels in hepatic DCs from obese mice.