Consistent with an increased proinflammatory activation profile of the DCs, we found that obesity altered the CD4+ Th cell pool in eWAT and liver, but not spleen, favoring Th1 cells at the expense of Th2 cells and Tregs in eWAT and increasing Th1 cells, Th17 cells, and Tregs in the liver. This evidence concerns the gene CD4 and obesity due to melanocortin 4 receptor deficiency.