All nine TFs, including FOXA1, HOXB13, EZH2, ONECUT2, SMAD2, MBD2, CTBP2, EWSR1, and PCGF2, have been previously reported to be associated with PCa (Srikantan et al. 2000, Varambally et al. 2002, Perttu et al. 2006, Pulukuri & Rao 2006, Ewing et al. 2012, Gerhardt et al. 2012, Takayama et al. 2014, Guo et al. 2019, Nicholas et al. 2021). This evidence concerns the gene SMAD2 and posterior cortical atrophy.