Interestingly, all of the identified TFs, namely, FOXA1, HOXB13, EZH2, SMAD2, MBD2, ONECUT2, CTBP2, EWSR1, and PCGF2, have been previously reported to be associated with PCa, highlighting common transcriptional regulation between protein-coding genes and long non-coding RNAs in PCa (Srikantan et al. 2000, Varambally et al. 2002, Perttu et al. 2006, Pulukuri & Rao 2006, Ewing et al. 2012, Gerhardt et al. 2012, Takayama et al. 2014, Guo et al. 2019, Nicholas et al. 2021). The gene discussed is SMAD2; the disease is posterior cortical atrophy.