Consistently, nucleocapsid-specific IFNγ−/CD107a+ and IFNγ+CD8+T-cell responses decreased more rapidly in individuals with PASC than in convalescent controls, suggesting a dysfunctional immune response (perhaps in response to persistent antigen stimulation) as a contributor to the ongoing clinical syndrome (Peluso et al., 2021). This evidence concerns the gene CD8A and long COVID-19.