Evidence for a potential pathogenic role of immune responses against latent pathogens in PASC, however, comes from recent reports pointing to EBV as a possible causative agent in MS (DeLorenze et al., 2006; Levin et al., 2005) and specifically highlighting (EBV-specific) CD8+ T cells as these cells play a key role in antiviral immunity and dominate the CNS immune infiltrate in MS (Salou et al., 2015; van Nierop et al., 2016). This evidence concerns the gene CD8A and myeloid sarcoma.