SARS-CoV-2-specific CD8+ T-cell responses of significantly increased breadth and magnitude, however, were observed in a small subset of individuals who remained positive for SARS-CoV-2 via RT-PCR nasopharyngeal testing up to 90 d following acute COVID-19, suggesting that such subjects might still harbor replicating virus that drives T-cell activation and evolution (Vibholm et al., 2021). This evidence concerns the gene CD8A and COVID-19.