Even after the additional adjustments for hypertension, dyslipidemia, overweight or obesity, T2DM, LDL, AST, ALT, and creatinine, participants with MAFLD still had a higher risk in the development of new incidents of CKD (adjusted HR 1.18, 95% CI 1.11-1.26). The gene discussed is GPT; the disease is type 2 diabetes mellitus.