Another review study showed that epigenetic changes in NRC31, SLCA4, BDNF, FKBP5, SKA2, OXTR, LINGO3, POU3F1, and ITGB1, all stress-related genes, were associated with depression, where glucocorticoid signaling (e.g., NR3C1 and FKBP5), serotonergic signaling (e.g., SLC6A4) and neuro epigenetic changes in dystrophin (e.g., BDNF) genes appear to be the most promising therapeutic targets for future research [54]. Here, LINGO3 is linked to major depressive disorder.