NR3C1 and depressive disorder: A meta-analysis showed that a homozygote mutation in NR3C1 rs41423247 was associated with depression in the total population (OR = 0.77, 95% CI = 0.64–0.94, P=0.01) and in Caucasians (OR = 0.78, 95% CI = 0.63–0.96, P=0.02) [30], and Cuzzoni et al. found that the NR3C1 rs41423247 (C/G) polymorphism may influence the onset of depression by altering the function of the glucocorticoid receptor [31].