Goel et al. identified a cohort with systemic lupus erythematosus (SLE)-like phenotype and particular renal involvement, but other STAT3 DN patients also showed characteristic increased expression of interferon-stimulated genes (ISGs), neutrophil extracellular trap (NET) formation, and anti-NET autoantibodies in the absence of autoimmunity phenotype [62]. The gene discussed is STAT3; the disease is Autoimmunity.