TP53 and neoplasm: Meanwhile, 20 and 40 ng/mL of paclitaxel were also found to significantly inhibit the expression of IMPA2 and upregulate the expressions of AIFM2 and p53 (Figure 5K‒M), suggesting that paclitaxel may exert its tumor-killing effect by regulating the expression of IMPA2/AIFM2/p53 and that IMPA2 may be a new target for the action of paclitaxel.