For a second example, TCRmodel2 was used to model the structure of a Class II TCR–pMHC interaction with a tumor-infiltrating lymphocyte TCR (named 4285-TCR1) that was found to target the common Class II MHC allele HLA-DRB1*13:01 and a p53 neoantigen with the R175H mutation (40). This evidence concerns the gene HLA-DRB1 and neoplasm.