Finally, impaired STING degradation has been found in models of neurological diseases including amyotrophic lateral sclerosis (ALS), Parkinson's disease and Niemann‐Pick disease type C, driven by deficiency of C9orf72 (McCauley et al, 2020), VPS13C (Hancock‐Cerutti et al, 2022) and Niemann‐Pick type C1 (NPC1; Chu et al, 2021), respectively. Here, NPC1 is linked to Niemann-Pick disease type C.