LYST and immunodeficiency disease: Additionally, mutations in Lysosomal trafficking regulator (LYST), which we found to be strongly phosphorylated at 30 min post DMXAA treatment (Fig EV2C) are causative in an immunodeficiency disease known as Chediak‐Higashi syndrome (CHS) (Windhorst et al, 1966; Burkhardt et al, 1993; Barbosa et al, 1996; Sepulveda et al, 2015).