This summary, however, oversimplifies the situation with considerable cross-talk existing between these cDC and T cell subsets as demonstrated by the fact that deletion of MHCII on XCR1+ cDC1 cells prevents initiation of anti-tumour CD4+ T cell responses and subsequent licensing of the cDC1 cells in a mouse model of melanoma [25]. Here, CD4 is linked to neoplasm.