Therefore, our HypoPP model can be further elaborated to recapitulate the broad HypoPP pathological conditions when additional channel/transporter components, such as Na+-K+-Cl−co-transporters, Na+-K+-ATPases or the CLC-1 (also known as CLCN1) chloride channel, are introduced into our HypoPP-model cells. This evidence concerns the gene CLCN1 and hypokalemic periodic paralysis.