Currently, gating pore currents due to noncanonical passage of ions through Cav1.1 or Nav1.4 channels are presumed to underlie HypoPP (Cannon, 2010; Matthews et al., 2009; Sokolov et al., 2007; Struyk and Cannon, 2007). The gene discussed is SCN4A; the disease is hypokalemic periodic paralysis.