Increasing EIS was strongly associated with inflammatory conditions such as peripheral vascular disease (standardized OR [95% CI] = 1.43 [1.13, 1.80]), myocardial infarction (1.45 [1.12, 1.87]), heart disease (1.38 [1.16, 1.65]), depression (1.29 [1.11, 1.49]) and chronic lung disease (1.67 [1.36, 2.06]), substantially more so than CRP, with the exception of hypertension, where the estimate for CRP was stronger (Figure 1c). This evidence concerns the gene CRP and heart disorder.