2019). Remarkably, our study showed that the activity of SOD was significantly higher in the vitamin D3-treated group (p < 0.05) compared to the VCM group. The same results have been reported by other investigators in experimental animals (Mokhtari-Zaer et al. 2020), in which SOD increased in the vitamin D3-treated group, which improved the cognitive impairments that occurred due to lipopolysaccharide. This evidence concerns the gene SOD1 and Cognitive impairment.