Indeed, the expression of Ryanodine receptors (RyR), which regulate the release of intracellular Ca2 + in the ER, varies during AD progression and the RyR fly homologue has been found as modifier of Abeta and tau toxicity in transgenic flies (Casas-Tinto et al., 2011; Feuillette et al., 2020). This evidence concerns the gene MAPT and Alzheimer disease.