Proteins believed to be involved in autophagy and mitophagy processes, such as Optineurin (OPTN), ATG5, ATG12, Beclin-1 (Bcl-1), PI3K class III, ULK1, AMBRA1, BNIP3, BNIP3L, FUNDC1, VDAC1, and VCP/P97 were decreased in AD brains (Martín-Maestro et al., 2017). This evidence concerns the gene OPTN and Alzheimer disease.