MFN2 and Charcot-Marie-Tooth disease type 2A1: Neuronal cells are in a constant state of high energy demand so they are considered to be especially vulnerable to dysfunction in the mitochondrial equilibrium as this can lead to abnormally low levels of ATP; specifically, there is an abundance of mutations in the MFN2 gene that have been commonly linked to a peripheral neuropathy caused by Charcot-Marie-Tooth disease Type 2A (CMT2A) (Kyriakoudi et al., 2021).