Cell lines expressing mutant APP or treated with Aβ (Schmidt et al., 2007; Diana et al., 2008; Wang et al., 2008b,2009; Calkins and Reddy, 2011; Manczak et al., 2011), AD mouse models (Smith et al., 1997; Li et al., 2004; Reddy et al., 2004; Caspersen et al., 2005; Manczak et al., 2006; Yao et al., 2009), and AD post-mortem brains (Parker et al., 1990; Gibson et al., 1998; Maurer et al., 2000; Butterfield et al., 2001, Dragicevic et al., 2010) are reported to have mitochondrial dysfunction. Here, APP is linked to Alzheimer disease.