ULK1 and Alzheimer disease: The mitochondrial structure and function in the brains of AD patients and mouse models change into a swollen round shape with deformed cristae, low ATP production, reduced LC3 recruitment to the mitochondria, dysfunctional AMP-activated protein kinase (AMPK), and inhibition of its targets ULK1 and TBK1, which collectively impairs the mitophagy process (Hirai et al., 2001; Martín-Maestro et al., 2016; Wang et al., 2017; Fang et al., 2019).