GLI1 and mesothelioma: In this study, we showed that SMO and GLI1 genes have a key role in tumor development, and our experimental results also showed that the GLI1 gene and its upstream SMO gene have a greater prognostic impact on mesothelioma patients, and we found that the survival time of mesothelioma patients was significantly longer when SMO and GLI1 genes were lowly expressed.