SMO and malignant mesothelioma: In the experiments of this paper, we also found that the expression levels of SMO and GLI1 proteins were higher in malignant mesothelioma tissues than in benign mesothelioma tissues, and by Spearman's correlation analysis, we found that SMO and GLI1 were positively correlated in mesothelioma, which is consistent with the above findings and provides some basis for the upstream and downstream relationship between SMO and GLI1 genes in mesothelioma.