The more obvious the mutation, the lower the SMO expression level (P = 0.001, Figure 3(e)); GLI1 gene expression level was closely related to lymph node metastasis in mesothelioma patients, especially in N1 and N3, and the higher the number of lymph node metastasis, the lower the GLI1 gene expression level (P = 0.009, Figure 3(f)). The gene discussed is GLI1; the disease is mesothelioma.