While SMO and GLI1 expression levels were associated with mesothelioma patients, Balancin et al., Shoji et al., and Maio et al. found that the occurrence and prognosis of malignant mesothelioma were associated with multiple factors, and risk factors for death were determined by multivariate Cox regression, and their study table showed that younger age, female, epithelioid histology, and multimodal treatment all improved patient survival [23–25]. This evidence concerns the gene SMO and malignant mesothelioma.