Although the precise correlation between DCs and SARS-CoV-2 in the mucosa has been poorly explored, SARS-CoV-2 accelerates the activation of PRR-linked signaling, including NLRP3 inflammasome or occasionally leads to the cytokine release syndrome (CRS) via robust production of proinflammatory mediators, such as interleukin (IL)-6, granulocyte-macrophage colony-stimulating factor, IL-1β, and tumor necrosis factor (TNF)-α during the CRS (74). The gene discussed is NLRP3; the disease is congenital rubella syndrome.