PLXDC1 and neoplasm: The genes encoding PLXDC1 are highly expressed during tumor angiogenesis and enriched in many types of tumor endothelial cells (144), including glioblastoma endothelium (57, 63), ovarian cancer (62), gastric cancer (60), renal cell carcinoma (61), colorectal cancer (64), lung cancer (58), breast cancer (56), and osteosarcoma (59).