and Park et al., studying neovascular age-related macular degeneration (nAMD) patients and an argon laser-induced choroidal neovascularization (CNV) model in BN rats confirmed that decreased PEDF expression levels were associated with oxidative damage to RPE cells and may lead to CNV formation, which is a key factor in AMD pathological changes (37, 174). The gene discussed is SERPINF1; the disease is age-related macular degeneration.